ABSTRACT
The authors study a patient carrying Aids, with exuberant dermatological manifestations of cryptococcosis. They stress the therapeutic effectiveness of short-term amphotericin B. The authors reviewed cases of cutaneous infection with Cryptococcus reported in the national and international literature, verifying that the frequency has increased with the AIDS epidemic. Also, they discuss about the differential diagnosis with some cases of dermatosis, particularly with the disseminated giant molluscum contagiosum. In relation to the therapy, they affirm that the choice of drug depends on the organ involved, as well as the immune state of the patient.
Os autores estudam um paciente portador de SIDA, com manifestações dermatológicas exuberantes de criptococose. Destacam a eficácia terapêutica da anfotericina B, a curto prazo. Revisam os casos de criptococose cutânea relatados na literatura nacional e internacional, ressaltando o aumento de sua freqüência com a epidemia da SIDA. Também discutem o diagnóstico diferencial com várias dermatoses, particularmente com o molusco contagioso gigante disseminado. Em relação à terapêutica, afirmam que a escolha da droga depende do órgão comprometido, assim como do estado imunológico do paciente.
Subject(s)
Humans , Male , Adult , AIDS-Related Opportunistic Infections/diagnosis , Cryptococcosis/diagnosis , Cryptococcus neoformans/isolation & purification , Dermatomycoses/diagnosis , AIDS-Related Opportunistic Infections/drug therapy , AIDS-Related Opportunistic Infections/pathology , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Cryptococcosis/drug therapy , Cryptococcosis/pathology , Dermatomycoses/drug therapy , Dermatomycoses/pathology , Fatal OutcomeABSTRACT
Relatamos a associação de dois casos distintos de neuromesoectodermose ocorridos em uma mesma família, um manifestado através da neurofibromatose tipo 1 e outro através da esclerose tuberosa. O encontro de dois distúrbios entre primos de primeiro grau, ocasionados por diferentes mutações genéticas e transmitidos por herança autossômica dominante, sugere uma possível correlação entre eles. Também são descritas as manifestações clínicas, suas conseqüências e os critérios diagnósticos das duas doenças, visando ressaltar a importância do diagnóstico precoce.
We relate the association of two distinct cases of neuromesoectodermosis occurred in a family, one manifested as neurofibromatosis type 1 and the other as tuberous sclerosis. The two anomalies at cousins, caused by different genetic mutations and transmitted by autosomal dominant inheritance, suggest a possible relation between them. Also, clinical manifestations are described, their consequences and the diagnostic criteria of both illnesses, emphatizing the importance of the precocious diagnosis.